Israeli missiles have hit a site in Iran, according to the US broadcaster ABC News, which cited an unnamed senior US official.
The Iranian state television reported explosions in Isfahan, as air defences were activated and flights across several areas including Tehran and Isfahan were suspended.
There were no reports of casualties. Nor was there an official response from Iran.
Israel promised to respond after Iran last Saturday launched a barrage of drones and missiles on the country, after a suspected Israeli strike on Iran’s consulate compound in Damascus killed a high-ranking commander.
There have also been reports of explosions in Syria and Iraq.
The United States and a number of European countries had been calling on Israel not to respond to the Iranian attack.
Isfahan is considered a strategically important city and one that is host to several important sites, including military research and development sites, as well as bases. The nearby city of Natanz is the location of one of Iran’s nuclear enrichment sites.
Commercial flights began diverting their routes early on Friday morning over western Iran without explanation as the semi-official Fars news agency in Iran said there had been “explosions” heard over the city of Isfahan.
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